Bone Research Society

BRS Annual Meeting 2020

6 - 8 July 2020

Online

Programme

Monday 6th July 2020

10.00 - 10.40

Muscle & Bone Oral Communications

Chairs: Dimitris Vlachopoulos (Exeter) & Sarah Allison (Surrey)

10.00

Cholecalciferol supplementation in pregnancy is associated with greater offspring bone and lean mass at 4 years: findings from the MAVIDOS randomised controlled trial

Elizabeth Curtis (Southampton)

 

10.10

Physical activity through adolescence and hip bone mineral density in young adults: prospective cohort and negative control study

Ahmed Elhakeem (Bristol)

 

10.20

How does radiographic knee osteoarthritis impact musculoskeletal aging in midlife? Findings from the Hertfordshire Cohort study

Nicholas Fuggle (Southampton)

 

10.30

Vertebral fractures and daily pain are associated with lower physical activity in postmenopausal women with back pain

Gallin Montgomery (Manchester)

 

 

11.30 - 12.15

Industry Symposium – Alexion

 

14.30 - 15.15

Industry Symposium – Kyowa Kirin

  

16.00 - 17.30

Rare Bone Disease Workshop

Kindly supported by Alexion & Kyowa Kirin

Chairs: Kassim Javaid (Oxford) & Zulf Mughal (Manchester)

16.00

Introduction and welcome

 

16.05

Case discussion: Is it metabolic bone disease?

Frank Rutsch (Münster, Germany)

 

16.20

Treating Hypophosphatasia in Adult: The UK experience

Katie Moss (London, UK)

 

16.35

Fibrodysplasia ossificans progressiva: current and potential therapies

Judith Bubbear (Stanmore, UK)

 

16.50

How to transition well - current practice and research needs

Jenny Walsh (Sheffield, UK)

 

17.05

Rare forms of OI; where are we heading

Frank Rauch (Montreal, Canada)

 

17.30 - 17.45 BREAK

17.45 - 18.25

Rare Bone Disease Workshop - Oral Communications

Chairs: Kassim Javaid (Oxford) & Zulf Mughal (Manchester)

17.45

Osteoarticular morbidity before and after disease modifying therapy in a cohort of patients with alkaptonuria in the United Kingdom National Alkaptonuria Centre

Lakshminarayan R Ranganath (Liverpool)

 

17.55

Tendon properties in a new mouse model of moderate-severe dominant Osteogenesis Imperfecta

Larissa Sinkam (Montreal, Canada)

 

18.05

Significantly impaired grip force in children with Neurofibromatosis Type 1

Amish Chinoy (Manchester)

 

18.15

A mouse model of juvenile onset X-linked osteoporosis

Bernard Freudenthal (London)

 

 

 

Tuesday 7th July 2020

10.00 - 10.40

Paediatric Bone Disease Oral Communications

Chair: Elizabeth Curtis (Southampton)

10.00

Lumbar spine quantitative computed tomography (QCT) is a better predictor of vertebral fracture in boys with Duchenne muscular dystrophy (DMD) than either DXA or peripheral QCT

Nicola Crabtree (Birmingham)

 

10.10

Children living with HIV in Zimbabwe have impaired trabecular and cortical bone architecture, despite treatment with anti-retroviral therapy

Cynthia Kahari (Harare, Zimbabwe)

 

10.20

The Impact of HIV on Skeletal Maturation in Zimbabwean Children and Adolescents

Farirayi Nyakoko (Harare, Zimbabwe)

 

10.30

Placental volume at 11 weeks is associated with offspring bone mass at birth and in later childhood: findings from the Southampton women’s survey

Stephen Woolford (Southampton)

 

 

14.00 - 14.40

Cancer & Bone Oral Communications

Chair: Leni Green (Sheffield)

14.00

Overall fracture incidence in multiple myeloma patients relative to general population controls: a parallel cohort study of the UK CPRD

Samuel Hawley (Oxford)

 

14.10

Interleukin-1B regulates metastatic breast cancer to bone; affects through tumour-associated innate immune response

Penelope Ottewell (Sheffield)

 

14.20

Inhibition of Autophagy Prevents Chemoresistance in High Grade Osteosarcoma

Janice Salena Pereira (London)

 

14.30

Assessing the Impact of Ovarian Suppression Therapy (OST) on Bone Health in Premenopausal Women Treated for Breast Cancer.

David Riley (Manchester)

 

 

16.00

Industry Symposium – UCB

 

 

Wednesday 8th July 2020

10.00 - 10.50

Bone Health Oral Communications

Chairs: Claire Clarkin (Southampton) & Elaine Dennison (Southampton)

10.00

Is fracture risk screening using Frax effective for secondary fracture prevention? A post-hoc analysis of the SCOOP trial

Camille Parsons (Southampton)

 

10.10

Associations between inflammation, adiposity and bone mineral density: do they differ between ethnicities in a UK-based tri-ethnic cohort?

Ruth Durdin (Southampton)

 

10.20

Near infrared spectroscopy for the investigation of vascular haemodynamics of human bone in vivo.

Robert Meertens (Exeter)

 

10.30

A stable form of sulforaphane, generates bone mass gains, is anti-osteoclastogenic in vitro and protects against pain onset in a spontaneous model of mouse OA

Polymnia Louka (London)

 

10.40

Characterisation of subchondral cysts in a murine model of spontaneous osteoarthritis

Rebecca Norman (London)

 

 

11.15 - 12.15

BRS Annual General Meeting (AGM) - members only

 

14.00 - 14.40

Basic Science Oral Communications

Chair: Isabel Orriss (London)

14.00

Decoding the biochemistry of matrix vesicles during biomineralisation: Is ENPP6 upstream of PHOSPHO1?

Scott Dillon (Edinburgh)

 

14.10

Mitoguardin-2 deficiency results in severe osteoporosis

David Komla Ebri (London)

 

14.20

Opposing effects of miR-138 and miR-181a/b-1 on bone formation and repair.

Audrey McAlinden (St Louis, USA)

 

14.30

Slc38a10 is a novel regulator of osteoblastic bone formation

Andrea Pollard (London)