See below for other related events.
26 January 2021, Virtual Seminar
Katherine Staines: Understanding growth plate fusion mechanisms
As growth slows and eventually ceases, the human growth plate narrows and bone bridges form to span its width. I will describe methods we have developed to understand these processes and how these may predict musculoskeletal health in later life.
KS completed her PhD at the Roslin Institute in 2012 with Colin Farquharson before completing postdoctoral positions with Colin and Andy Pitsillides. She was awarded a Vice Chancellor’s Fellowship at Edinburgh Napier in 2017 before taking a Senior Lectureship position in Brighton at the start of 2020.
Rachel Lopera-Burgueno: The role of regulatory T-cells in osteoarthritis
RLB is a 3rd year PhD student in KS lab also supervised by Graham Wright at Edinburgh Napier University working on the role of regulatory T cells in OA.
The webinar will take place on Tuesday 26th January at 14:00. Join us at https://zoom.us/j/93621652894.
23 February 2021, Virtual Seminar
Musckuloskeletal modelling of forces transmitted to the joints during walking and the anatomical properties involved.
22 March 2021, Virtual Sessions Update
Given the uncertainties for 2021, the clinical training course will now be run virtually as a series of live and pre-recorded sessions. More information about the dates of the sessions, programme and registration will be available soon.
30 March 2021, Virtual Seminar
Engineered bone marrow niches for hematopoietic stem/progenitor cells
27 April 2021, Virtual Seminar
Adam Pickard "A non-canonical secretory route for collagen assembly".
Adam is a senior postdoc in Karl Kadler’s lab (Wellcome Centre for Cell-Matrix Research, University of Manchester) studying how cells assemble a collagen-rich extracellular matrix. Published findings from our lab show that cells assemble collagen fibrils under circadian clock control, and that disruption of the clock produces abnormal fibrils that accumulate in numbers. However, earlier work published in 2004 from the Kadler group showed that cells in vivo can secrete procollagen within minutes. My recent work has focused on reconciling these apparently contradictory observations. In his talk, Adam will explain how he has used CRISPR-Cas9 editing and cell culture models to identify a non-classical secretory pathway of collagen secretion. His work has identified an unexpected role of lysosomal compartments in collagen secretion. These observations have relevance to fibrosis, in which uncontrolled deposition of collagen leads can cause death. He with new approaches, using nanoluciferase, to screen for collagen modulatory compounds.
Joan Chang “Understanding the role of endosomal recycling in collagen-I fibril formation”
Joan received her PhD in cancer studies from the lab of Janine Erler (Institute of Cancer Research, University of London), then went on to study adipocytes in the tumour microenvironment at UNC Chapel Hill with Dr Andrew Dudley. In 2016 Joan moved to Karl Kadler's lab where she made discoveries concerning the circadian regulation of collagen fibril assembly. Her recent work is showing that a crucial step in this process is uptake of collagen via the endosomal system. In her talk, Joan will show her recent data on endosomal trafficking using mass spectrometry and a novel method of fluorescence activated sorting of transport vesicles.
Richa Garva “To understand the role of type I collagen in determining cell fate, with translational opportunities for osteoarthritis"
Like Adam and Joan, Richa is a senior postdoc in Karl's lab. Richa approached the question of the purpose of the circadian collagen seen in adult mouse tendon by preforming a conditional knockout of col1a1 by crossing Col1a2CreERT2 and Col1a1-floxed mice, and feeding tamoxifen postnatally. To her surprise, fibroblasts that cannot synthesise col1a1 (and therefore cannot make collagen-I) switch to making collagen-II and express other chondrogenic markers including aggrecan, Sox9 etc. These data hint at a new role for Col1a1 in determining cell fate, and open up potential strategies for treating osteoarthritis.
28-30 June 2021, Virtual Meeting
BRS 2021 28 - 30 June 2021
Given the uncertainties for 2021, we are planning a virtual 3-day meeting from 10am to 3pm on Monday 28th to Wednesday 30th June 2021.
The programme will be delivered on the zoom platform to ensure reliability. It will be a mix of oral presentations from international and national experts across a range of research areas bringing together basic and clinical science. There will also be a focus on presentations from abstract submissions with time for lively discussions.
Do hold these dates in your diary and look out for the abstract and registration deadlines which we will publish soon.
30 June - 2 July 2021, Dublin, Ireland
A 3-day immersive international course giving the opportunity to learn about and discuss mechanisms, clinical diagnosis and treatment of paediatric bone disorders.
3-6 July 2021, University College, Dublin, Ireland
Abstract deadline: 15 February 2021
This Conference will bring together scientists and clinicians from a wide range of disciplines to gain a better understanding of the growing skeleton in health and disease. The scope ranges from basic molecular mechanisms to clinical aspects, from bone physiopathology to treatment. We invite anyone with an interest in bone metabolism and bone mass in children, adolescents and young adults to attend. The ICCBH conference takes place every two years. The 2019 meeting was attended by over 500 delegates from across the globe, making it truly multinational and multidisciplinary – a unique networking opportunity.
1-4 September 2021, Sheffield, UK
It is with great pleasure we invite you to participate in the 14th International Conference on Osteogenesis Imperfecta (OI2020) in Sheffield, UK, on 1 to 4 September 2021 (postponed from 5-8 September 2020).
The meeting will offer a high quality scientific programme of interest to both clinical and basic scientists. We’re expecting between 200 and 250 delegates from across the globe, including many key opinion leaders in the field.
The multidisciplinary nature of the conference provides an opportunity to talk to specialists from many different fields including geneticists, internists, endocrinologists, orthopaedic surgeons, dentists, radiologists, paediatricians, physiotherapists, nurses and others working with osteogenesis imperfecta.
1-4 October 2021, Toronto, Canada
7-9 October 2021, Ljubljana, Slovenia
We hereby announce the new dates for the 39th Annual Meeting of the European Bone and Joint Infection Society, which will take place in Ljubljana, Slovenia, 7-9 October 2021.
The main conference theme is:
Joining forces: optimising diagnosis and management of bone and joint infections
The programme topics are:
· Optimising antibiotic treatment of bone & joint infections
· Optimal bone infection sampling and microbiological processing
· Low-grade PJI – what is the best approach?
· Musculoskeletal infections in children
· Infections of arthroscopic implants, osteotomies and tendon reconstructions
· Chronic osteomyelitis with good function. To treat or to live with?
· Spinal infections
· Fracture-related infections
Find more information on the conference website: www.ebjis2021.org
26 January 2021, Virtual Seminar
News, 15 May
1-4 October 2021, Toronto, Canada