Bone Research Society

Bringing basic and clinical researchers together since 1950

Positions Available

Jobs can be publicised here free of charge.  Simply send details to web@boneresearchsociety.org.

Adverts should contain a very brief description (maximum three sentences), an e-mail address or web location for obtaining further details, and the closing date.

Other useful websites when looking for jobs are jobs.ac.uk (University positions in the UK) and www.academicjobseu.com (Europe-wide).

 

Two positions: The Fractures-E3 Epidemiologist/Project Manager and Statistician/Data Manager

University of Bristol
University of Bristol
Closing date: Sun 1 Mar 2020

We are advertising two posts at the University of Bristol for our NIHR-Wellcome Funded 5 year Fractures-E3 study (Fractures in Sub-Saharan Africa: epidemiology, economic impact and ethnography), which is based in Bristol working with overseas partners in The Gambia, Zimbabwe and South Africa, and UK partners in Southampton and Oxford.

The details of the two posts are here:

The Fractures-E3 Epidemiologist and Project Manager

http://www.bristol.ac.uk/jobs/find/details.html?nPostingID=64474&nPostingTargetID=182158&option=28&sort=DESC&respnr=1&ID=Q50FK026203F3VBQBV7V77V83&JobNum=acad104441&Resultsperpage=10&lg=UK&mask=uobext

and

The Fractures-E3 Statistician and Data Manager

http://www.bristol.ac.uk/jobs/find/details.html?nPostingID=64535&nPostingTargetID=182167&option=28&sort=DESC&respnr=1&ID=Q50FK026203F3VBQBV7V77V83&keywords=Statistician&Resultsperpage=10&lg=UK&mask=uobext

Closing date 1st March

Interview date 9th March

Celia.gregson@bristol.ac.uk

PhD - Role of Bacteria-Purinoceptor Interactions in Pathological Changes Leading to Implant Failure

University of Portsmouth
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
Closing date: Sun 23 Feb 2020

Applications are invited for a fully funded three-year PhD to commence in October 2020.

The PhD will be based in the Faculty of Science and Health, and will be supervised by Professor Darek Gorecki and Professor Chris Luca.

This PhD studentship is one of six PhD studentships funded by the University of Portsmouth in the area of biomaterials and bioengineering. These studentships will support the University’s strategic plan engaging with clinicians working in Portsmouth Hospital Trust to solve real-life medical problems. The successful applicants would be part of a cross-faculty research cluster in medical technologies. This programme of research involves several Schools based in the Faculty of Science and Health and the Faculty of Technology. The vision of the cluster is to train a cohort of PhD students who contribute to the academic environment, some of whom would be expected to develop academic careers in this expanding area whilst others would be employed in the growing international medical technologies industry. Training would be enhanced by extended visits to other institutions involved in similar research and by visits to hospitals to meet with clinicians involved in the research projects

Read more...
Professor Goreki (darek.gorecki@port.ac.uk)

PhD - The role of P2X7 purinoceptor-bacteria interactions in the pathophysiology and treatment of Periodontitis

University of Portsmouth
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
Closing date: Sun 23 Feb 2020

Applications are invited for a fully-funded three year PhD to commence in October 2020.

The PhD will be based in the Faculty of Science and Health, and will be supervised by Dr Sarah Fouch, Professor Darek Gorecki and Dr Kristina Wanyonyi.

The work on this project will involve:
● Working with clinical samples, from varying geographical locations, to contribute and enhance understanding of the bacterial species and expression levels of P2X7 associated with the initial and chronic phases of periodontitis.
● Investigating the bacterial/P2X7 interactions to identify their importance in periodontitis.
● Evaluating potential treatment targets for both the initial and chronic phases of periodontitis.

This project brings together expertise within Microbiology, Dentistry and Biochemistry to contribute and enhance understanding of Periodontitis, a disease affecting 45% of the population (1) that has a significant health impact. Periodontitis causes the destruction of periodontal connective tissue, bone and ultimately tooth loss but also increases the risk of several systemic conditions including cardiovascular disease, diabetes and obesity.

Periodontitis is a pathology cause by a hyperimmune response against bacteria in the oral cavity. Aimed primarily at pathogen elimination, the host defence includes activation of acquired and innate immunity triggered by extracellular ATP (eATP) released from damaged cells acting on the P2X7 ATP receptor (purinoceptor) (2,3). However, P2X7 activation can result in both positive and negative clinical outcomes depending on a range of factors (4).

The current project aims to use molecular, biochemical and classical culture methods to identify and determine P2X7/bacterial interactions to ascertain the role of such interplay in differing stages of periodontal disease and identify whether modulation of P2X7 receptors can alter the disease progression

Read more...
Dr Sarah Fouch (sarah.fouch@port.ac.uk)

PhD - DMD gene in development and cancer

University of Portsmouth
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
Closing date: Sun 23 Feb 2020

Applications are invited for a fully-funded three year PhD to commence in October 2020.

The PhD will be based in the Faculty of Science and Health, and will be supervised by Dr Matt Parker and Prof Darek Gorecki.

This project is part of an interdisciplinary programme of research led by Profs Darek Gorecki and Matt Guille and Drs Rhiannon McGeehan and Matt Parker.

DMD gene mutations result in Duchenne Muscular Dystrophy, which gave the gene its name. However, new data from our and other laboratories indicate that DMD mutations trigger downstream multi-system abnormalities going far beyond the mechanical instability in myofibres. These alterations are diverse and affect proliferation and signalling in specific cells, mitochondrial functions and metabolism and even oncogenesis. Moreover, cognitive deficits found in Duchenne patients are caused by distinctive molecular alterations resulting from DMD gene mutations in the brain cells. Given this increasing range of defects, identifying novel pathological mechanisms triggered by DMD mutations would advance our understanding of potential new roles of this largest human gene known in human health and disease.

The strategic aim of the three interdisciplinary PhDs is to expand DMD research into new areas by exploiting novel findings and high quality preliminary data. The projects are mutually supporting, creating the critical mass, using several animal models offering cross-species validation of findings and access to the university infrastructure across the faculties. They also involve 10 external partners offering laboratory placements and an extensive range of expertise. Therefore, while the majority of work will be undertaken in Portsmouth, each PhD student will spend a short period at a collaborating laboratory.

Read more...
Prof Darek Gorecki (darek.gorecki@port.ac.uk) or Dr Matt Parker (matthew.parker@port.ac.uk)

PhD - Role of DMD gene in development and function of white blood cells

University of Portsmouth
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
Closing date: Sun 23 Feb 2020

Applications are invited for a fully-funded three-year PhD to commence in October 2020.

The PhD will be based in the Faculty of Science and Health, and will be supervised by Prof Darek Gorecki and Prof Matt Guille.

This project is part of an interdisciplinary programme of research led by Profs Darek Gorecki and Matt Guille and Drs Rhiannon McGeehan and Matt Parker.

DMD gene mutations result in Duchenne Muscular Dystrophy, which gave the gene its name. However, new data from our and other laboratories indicate that DMD mutations trigger downstream multi-system abnormalities going far beyond the mechanical instability in myofibres. These alterations are diverse and affect proliferation and signalling in specific cells, mitochondrial functions and metabolism and even oncogenesis. Moreover, cognitive deficits found in Duchenne patients are caused by distinctive molecular alterations resulting from DMD gene mutations in the brain cells. Given this increasing range of defects, identifying novel pathological mechanisms triggered by DMD mutations would advance our understanding of potential new roles of this largest human gene known in human health and disease.

The strategic aim of the three interdisciplinary PhDs is to expand DMD research into new areas by exploiting novel findings and high quality preliminary data. The projects are mutually supporting, creating the critical mass, using several animal models offering cross-species validation of findings and access to the university infrastructure across the faculties. They also involve 10 external partners offering laboratory placements and an extensive range of expertise. Therefore, while the majority of work will be undertaken in Portsmouth, each PhD student will spend a short period at a collaborating laboratory.

Read more...
Prof Darek Gorecki (darek.gorecki@port.ac.uk) or Prof Matt Guille (matt.guille@port.ac.uk)

PhD - Molecular mechanisms of cognitive impairment caused by DMD gene mutations

University of Portsmouth
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
Closing date: Sun 23 Feb 2020

pplications are invited for a fully-funded three year PhD to commence in October 2020.

The PhD will be based in the Faculty of Science and Health, and will be supervised by Prof Darek Gorecki, Dr Rhiannon McGeehan and Dr Matt Parker.

This project is part of an interdisciplinary programme of research led by Profs Darek Gorecki and Matt Guille and Drs Rhiannon McGeehan and Matt Parker.

DMD gene mutations result in Duchenne Muscular Dystrophy, which gave the gene its name. However, new data from our and other laboratories indicate that DMD mutations trigger downstream multi-system abnormalities going far beyond the mechanical instability in myofibres. These alterations are diverse and affect proliferation and signalling in specific cells, mitochondrial functions and metabolism and even oncogenesis. Moreover, cognitive deficits found in Duchenne patients are caused by distinctive molecular alterations resulting from DMD gene mutations in the brain cells. Given this increasing range of defects, identifying novel pathological mechanisms triggered by DMD mutations would advance our understanding of potential new roles of this largest human gene known in human health and disease.

The strategic aim of the three interdisciplinary PhDs is to expand DMD research into new areas by exploiting novel findings and high quality preliminary data. The projects are mutually supporting, creating the critical mass, using several animal models offering cross-species validation of findings and access to the university infrastructure across the faculties. They also involve 10 external partners offering laboratory placements and an extensive range of expertise. Therefore, while the majority of work will be undertaken in Portsmouth, each PhD student will spend a short period at a collaborating laboratory.

Read more...
Prof Darek Gorecki (darek.gorecki@port.ac.uk)

Group Leader in Rheumatic and Musculoskeletal Disorder Tissue Engineering

KU Leuven
KU Leuven
Closing date: Thu 12 Mar 2020

The Department of Development and Regeneration of the Group Biomedical Sciences includes basic, translational and clinical researchers in the field of embryology and stem cell biology, human reproduction, pre-and postnatal developmental processes and the wider scope of regenerative medicine including orthopedics, physical therapy,
rheumatology, urologic, gynecologic and abdominal surgeons. The Skeletal Biology and
Engineering Research Center (SBE) within the Department focuses its research on the
understanding of the cellular and molecular basis of skeletal tissue formation,
remodeling, disease and repair. By integrating insights into development, growth,
homeostasis and skeletal disease, the Center aims to identify and develop potential
treatments for rheumatic and musculoskeletal disorders (RMDs), including regenerative
strategies for cartilage, bone and joint repair, in a multidisciplinary environment
comprising engineers, clinicians, and biologists. There is a full time academic research position in the area of tissue engineering with a specific focus on RMDs. We are looking for internationally oriented candidates with an excellent publication record, a strong interest in interdisciplinary research and with educational competence within the field of RMDs and regenerative medicine.
Website Biomedical Sciences Group: https://gbiomed.kuleuven.be/english
Website Department of Development and Regeneration: https://gbiomed.kuleuven.be/english/research/50000640

Read more...

Post-doctoral Research Scholar

University of California at Davis, School of Medicine, and Division of Rheumatology
UC Davis Medical Center, Shriners Hospitals-Northern California

The successful candidate will work in a NIH-funded laboratory with access to state-of-the-art facilities that investigates cytokine regulation of autoimmunity. Self-motivated, scholars that demonstrate passion for research and a comprehensive working knowledge of common in vivo laboratory techniques in the field of bone biology and/or immunology/dermatology are encouraged to apply. A PhD, or MD/PhD in a relevant field and a strong publication record is required. Fluency in English is essential.

Successful candidates will benefit from a dynamic and highly collaborative environment and the opportunity to interact with the extended scientific community at UC Davis, which ranks among the top 10 public research universities in the US, and will be encouraged to present their research at international meetings. For more information about the lab and research projects available please visit www.adamopouloslab.com.

To be considered for the position, please send in a single PDF a detailed CV with methodological expertise, a list of scientific publications, and the contact details of three referees to Iannis@ucdavis.edu. Salary will be according to NIH scale and commensurate with experience. Position available immediately.

Read more...
Iannis@ucdavis.edu

Research job opportunity

Gérontopôle of the Toulouse University Hospital
Toulouse, France

The Gérontopôle of the Toulouse University Hospital (France) is an internationally-recognized institution for clinical research on age-related conditions, in particular in Alzheimer's disease, frailty and sarcopenia (maintaining autonomy) and nursing homes. With more than 400 healthcare professionals, and given its infrastructures, expertise, and clinical care facilities, the Gérontopôle was selected by the French Ministry of Health and the Secretary of State for Older Adults as national center of excellence. Furthermore, in 2017, the Gérontopôle was designated WHO Collaborating Center for Frailty, Clinical Research and Geriatric Training.

The Gérontopôle is currently recruiting post-docs to be involved in the ongoing research programs in Toulouse (France). Candidates should be able to enhance the Gérontopôle studies through the publication of scientific articles in peer-reviewed journals. Post-docs with PhD in a relevant discipline (e.g., epidemiology, gerontology) should therefore master fluent scientific english, be able to perform statistical analysis and use related software and be globally autonomous in writing articles. Posts are for full-time and fixed-term (period of one year, renewable for one year) appointments.

Applications should include:
• A brief cover letter explaining why you would like to join our Institute (1 page maximum),
• Your Curriculum Vitae including your publications list (no more than 3 pages),
• The PDF files of one or two full-text articles of yours.

Applicants should send all these documents by e-mail to Constance de Seynes (constance.de-seynes@univ-tlse3.fr) who will forward them to the appropriate person. Please use as object of your e-mail “Application for a position at the Gérontopôle”. Shortlisted applicants will be contacted for a phone interview and a subsequent in-person interview in Toulouse.

CALL FOR APPLICATIONS (POSTDOC AND PHD) IN BONE PATHOPHYSIOLOGY

Humanitas Clinical and Research Centre
Milan Italy

The “Beppe and NuccyAngiolini” Foundation is a not-for-profit organization whose mission is to improve health and well-being through advances in basic and translational research on bone and joint pathophysiology with focus on inflammation, immunity and infectious or neoplastic diseases.
The “Beppe and NuccyAngiolini” Foundation calls for application for two positions (post-doctoral fellow and PhD student) to conduct research projects in the general field of its mission at the Humanitas Clinical and Research Center, Rozzano, Milan, Italy (www.humanitas-research.organd www.humanitasricerca.org) and Istituto di RicercheFarmacologicheMario Negri, Milan, Italy (www.marionegri.it).
Candidates must have aPhD (for the post-doctoral fellowship) or a Master degree (for the PhD studentship), a high degree of motivation in academic research and a good ability to work independently. Skills in cellular and molecular biology, immunology, microbiology and protein biochemistry are required. The two Institutions offer a vibrant, lively environment and access to state of the art technology.
Interested candidates should send their CV for inquiries to direzione.scientifica@humanitasresearch.it

direzione.scientifica@humanitasresearch.it