Jobs can be publicised here free of charge. Simply send details to email@example.com.
Adverts should contain a very brief description (maximum three sentences), an e-mail address or web location for obtaining further details, and the closing date.
Schools of Biosciences and Engineering
Closing date: Thu 14 Nov 2019
Could anti-inflammatory treatment at ACL reconstruction improve biological, functional and clinical outcomes?
Dr D Mason
Prof C A Holt
This project will test the hypothesis that inflammation after ACL reconstruction surgery is detectable in the joint fluids and blood, and reduces joint function and surgical outcomes; and that anti-inflammatory medication reduces inflammation and improves joint function and surgical outcomes.
Background to project
Osteoarthritis affects 8.5 million people in the UK and is a painful, debilitating and progressive condition with no cure apart from eventual surgical removal, fusion or replacement of the affected joint.
Osteoarthritis is commonly secondary to previous joint trauma. Such post-traumatic osteoarthritis (PTOA) accounts for ~12% of the current osteoarthritis population. Since these injuries often arise from sporting activities, individuals affected by PTOA are often affected at a young age (5-15 years after injury).
Not only does this contribute to a significant burden of pain and disability within the working age population, but existing treatments such as joint replacements are less well tolerated in this age group.
One such injury is anterior cruciate ligament (ACL) rupture of the knee, which leads to osteoarthritis in 50% of patients. Many patients will undergo ACL reconstruction surgery to stabilise the joint but, such surgery does not prevent PTOA, and may actually be detrimental due to the inflammation caused.
The project plan represents an ambitious and significant academic challenge for the knowledge base. The interactions between joint biology, joint mechanics and therapeutic outcomes are often poorly understood and difficult to measure, with few efficacy indicators.
The supervisory team applies their expertise in disease mechanisms and functional biomechanics to investigate orthopaedic conditions and thus guide improvements in patient care.
University of California at Davis, School of Medicine, and Division of Rheumatology
UC Davis Medical Center, Shriners Hospitals-Northern California
The successful candidate will work in a NIH-funded laboratory with access to state-of-the-art facilities that investigates cytokine regulation of autoimmunity. Self-motivated, scholars that demonstrate passion for research and a comprehensive working knowledge of common in vivo laboratory techniques in the field of bone biology and/or immunology/dermatology are encouraged to apply. A PhD, or MD/PhD in a relevant field and a strong publication record is required. Fluency in English is essential.
Successful candidates will benefit from a dynamic and highly collaborative environment and the opportunity to interact with the extended scientific community at UC Davis, which ranks among the top 10 public research universities in the US, and will be encouraged to present their research at international meetings. For more information about the lab and research projects available please visit www.adamopouloslab.com.
To be considered for the position, please send in a single PDF a detailed CV with methodological expertise, a list of scientific publications, and the contact details of three referees to Iannis@ucdavis.edu. Salary will be according to NIH scale and commensurate with experience. Position available immediately.
Gérontopôle of the Toulouse University Hospital
The Gérontopôle of the Toulouse University Hospital (France) is an internationally-recognized institution for clinical research on age-related conditions, in particular in Alzheimer's disease, frailty and sarcopenia (maintaining autonomy) and nursing homes. With more than 400 healthcare professionals, and given its infrastructures, expertise, and clinical care facilities, the Gérontopôle was selected by the French Ministry of Health and the Secretary of State for Older Adults as national center of excellence. Furthermore, in 2017, the Gérontopôle was designated WHO Collaborating Center for Frailty, Clinical Research and Geriatric Training.
The Gérontopôle is currently recruiting post-docs to be involved in the ongoing research programs in Toulouse (France). Candidates should be able to enhance the Gérontopôle studies through the publication of scientific articles in peer-reviewed journals. Post-docs with PhD in a relevant discipline (e.g., epidemiology, gerontology) should therefore master fluent scientific english, be able to perform statistical analysis and use related software and be globally autonomous in writing articles. Posts are for full-time and fixed-term (period of one year, renewable for one year) appointments.
Applications should include:
• A brief cover letter explaining why you would like to join our Institute (1 page maximum),
• Your Curriculum Vitae including your publications list (no more than 3 pages),
• The PDF files of one or two full-text articles of yours.
Applicants should send all these documents by e-mail to Constance de Seynes (firstname.lastname@example.org) who will forward them to the appropriate person. Please use as object of your e-mail “Application for a position at the Gérontopôle”. Shortlisted applicants will be contacted for a phone interview and a subsequent in-person interview in Toulouse.
Humanitas Clinical and Research Centre
The “Beppe and NuccyAngiolini” Foundation is a not-for-profit organization whose mission is to improve health and well-being through advances in basic and translational research on bone and joint pathophysiology with focus on inflammation, immunity and infectious or neoplastic diseases.
The “Beppe and NuccyAngiolini” Foundation calls for application for two positions (post-doctoral fellow and PhD student) to conduct research projects in the general field of its mission at the Humanitas Clinical and Research Center, Rozzano, Milan, Italy (www.humanitas-research.organd www.humanitasricerca.org) and Istituto di RicercheFarmacologicheMario Negri, Milan, Italy (www.marionegri.it).
Candidates must have aPhD (for the post-doctoral fellowship) or a Master degree (for the PhD studentship), a high degree of motivation in academic research and a good ability to work independently. Skills in cellular and molecular biology, immunology, microbiology and protein biochemistry are required. The two Institutions offer a vibrant, lively environment and access to state of the art technology.
Interested candidates should send their CV for inquiries to email@example.com
21-22 November 2019, INOX Conference Suite, University of Sheffield
Manchester Metropolitan University
1-4 October 2021, Toronto, Canada