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Edinburgh Napier University
Closing date: Fri 9 Feb 2018
This project is one of 13 four year PhD Studentships funded by Medical Research Scotland (http://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and Company. The Studentship will provide the first-class academic and commercial training needed to equip the successful candidate for a science career in an increasingly competitive market.
"Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis" to be delivered by the Edinburgh Napier University [Supervisors: Dr Katherine Staines (School of Applied Sciences, Edinburgh Napier University), Dr Craig Stevens (School of Applied Sciences, Edinburgh Napier University) and Professor Colin Farquharson (Roslin Institute, University of Edinburgh)] and Biogelx Ltd (www.biogelx.com) [Company supervisor: Dr Laura Goldie].
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately produces pain and the impairment of normal activities and quality of life. Currently we are unable to treat those with osteoarthritis, nor are we able to identify those at risk from disease onset, due to a lack of understanding as to the basic underpinning mechanisms at the articular cartilage: subchondral bone interface. This has been hindered somewhat by the current methods available for osteoarthritis research. Therefore, this project will look to develop a new experimental model which will include cells from all adjoining joint tissues to understand their interactions in the healthy, and the diseased joint. This model and the research data generated from its use in this project, will ultimately advance our understanding of the cellular and molecular mechanisms contributing to osteoarthritis development.
Enquiries should be sent by email to Dr Katherine Staines:
Candidates must have obtained, or expect to obtain, a minimum 2.1 undergraduate degree, or equivalent for degrees obtained outside the UK, in a relevant biomedical related discipline.
Candidates should complete the online application form available at:
Please include in the personal statement (a) a brief description of relevant experience and skills, (b) an indication of what the applicant would uniquely bring to the project and (c) a statement of how this project fits with the applicant’s future direction. Please note, a Research Proposal is not required for this project.
Interviews are expected to take place approximately 3-4 weeks after the closing date for applications.
It is anticipated that the PhD Studentship will start in September 2018.
Department of Medicine, Faculty of Medicine and Health Sciences at the University of East Anglia
Closing date: Thu 1 Feb 2018
We have a vacancy for a PhD studentship in the Musculoskeletal Research Group. This group undertakes research into factors that regulate the maintenance of a healthy musculoskeletal system as well as those involved in variety of pathologies.
Bone and renal metabolism is regulated by common factors and there is extensive cross-talk between these organs. This is referred to as the renal-bone axis. Ageing is associated with renal impairment, increased resistance to the regulating hormones and consequently changes in the renal-bone axis. Vitamin D may slow this ageing process. The mechanisms of these age-related changes and the effects of vitamin D are poorly understood.
Objectives of the PhD:
The focus of this PhD will be to investigate these mechanisms in order to identify and evaluate targets for the prevention and progression of renal impairment and disorders of bone metabolism in older people. The project will initially utilise existing data and samples derived from a randomised controlled trial in older people supplemented with vitamin D (collaboration Newcastle University). In the second phase, a study will be set up investigation vitamin D metabolism using a novel tracer technique.
The student will carry out data processing and analyses, laboratory analyses and in the second phase, conduct a study with human participants/patients. It is expected that the student will prepare and publish at least 2 high impact scientific papers.
Applicants should have an interest in statistical analyses, endocrinology and laboratory work and should have an affinity for working with study participants. Comprehensive training in these disciplines and other required skills will be provided.
Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject, e.g. biochemistry, physiology, nutrition, chemistry, medicine.
Successful completion of this PhD is anticipated to open opportunities to pursue a career in medical and health sciences, public health or bio-technical industry.
Academic environment and Funding notes
The Faculty of Medicine and Health Sciences is located at Norwich Research Park. There is access to extensive research facilities and clinical and non-clinical expertise, including health statistics, clinical trial units and state-of the art biochemical equipment. Further information about research at the Faculty of Health Sciences at the University of East Anglia can be obtained from the website (https://www.uea.ac.uk/medicine-health-sciences/research). Informal enquiries are welcomed to Dr Inez Schoenmakers (I.Schoenmakers@uea.ac.uk).
*This PhD project is funded by the Faculty of Medicine and Health Sciences for 3 years and comprises home/EU fees (£4,195), an annual stipend of £14,296 and £1000 per annum to support research training. International students are welcome to apply but will need to be able to meet the difference between Home/EU fees and Overseas Fees (£18,000).
Edinburgh Napier University
New Investigator representative
Bone formation by cultured osteoblasts
26-28 March 2018, Merton College, Oxford, UK