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Adverts should contain a very brief description (maximum three sentences), an e-mail address or web location for obtaining further details, and the closing date.
University of Southampton
Closing date: Mon 31 Aug 2020
Supervisor: Philipp Schneider
Co-supervisor Nicholas Harvey, Kate Ward, Cyrus Cooper
This PhD project offers a unique interdisciplinary life sciences experience at the interface of medicine, biomedical imaging and computational engineering, with the aim to better understand life influences on bone quality in children and tweenagers. You will work closely together with colleagues across Bioengineering in the Faculty of Engineering and Physical Sciences (https://www.feps.soton.ac.uk), μ-VIS X-ray Imaging Centre (www.muvis.org) and the MRC Lifecourse Epidemiology Unit (LEU) (www.mrc.soton.ac.uk) in Southampton.
Risk of osteoporosis, a condition in older age which leads to broken bones with minimal trauma, starts to accrue from before birth. Maternal factors during pregnancy such as vitamin D insufficiency are associated with reduced offspring bone mineral density (BMD), which is assessed by 2D dual-energy X-ray absorptiometry (DXA), which is often blind to the deteriorated 3D bone structure, which can lead to decreased bone strength and increased fracture risk. New high-resolution peripheral quantitative computed tomography (HRpQCT) permit a step change in non-invasive in vivo 3D bone assessment capability.
Such image-based 3D bone structural measures from HRpQCT have been shown to predict incident fractures in adulthood, independently of the standard BMD measures from clinical 2D DXA, while the relevant 3D bone structural determinants in childhood are unknown. At the MRC LEU at University Hospital Southampton HRpQCT scans are being undertaken on children at 6-8 years old who were born into the MAVIDOS trial (https://www.mrc.soton.ac.uk/web2/cohorts/mavidos-maternal-vitamin-d-osteoporosis-study). BMD assessment using DXA has suggested a positive effect on offspring bone mass. HRpQCT scans, at 11-13 years old, are also being undertaken on children born to the Southampton Women’s Survey (www.mrc.soton.ac.uk/sws).
The student will first investigate in MAVIDOS whether and to what extent maternal vitamin D supplementation in pregnancy leads to altered bone quality, and thus to decreased bone strength in the offspring. Secondly, in the Southampton Women’s Survey, the student will study associations between exposure to maternal and postnatal diet, growth, puberty, and bone quality and strength at 11-13 years. The study aims are:
(1) Implement standardised and (semi-)automated workflow for HRpQCT data for (i) segmentation and (ii) quantification of bone structure/
(2) Establish fully automated finite element analysis (FEA) framework for HRpQCT data.
(3) Visualise and analyse the link between bone structure/material properties and bone mechanics.
(4) Investigate links between maternal vitamin D supplementation and offspring bone microarchitecture and strength, with further analysis of effect modifiers such as key genetic loci and maternal/childhood environmental exposures.
The findings from this interdisciplinary project will yield novel information on the effect of intrauterine vitamin D exposure on the subsequent development of bone quality and biomechanical strength. Analysis of genetic and environmental effect modifiers will allow approaches to be stratified to individuals. The project findings will thus directly inform population approaches to pregnancy and early childhood health.
An undergraduate degree (minimum UK 2:1 honours degree).
Funding: tuition fees for EU/UK students. Stipend of £15,285 pa for up to 3.5 years UK only.
University of California at Davis, School of Medicine, and Division of Rheumatology
UC Davis Medical Center, Shriners Hospitals-Northern California
The successful candidate will work in a NIH-funded laboratory with access to state-of-the-art facilities that investigates cytokine regulation of autoimmunity. Self-motivated, scholars that demonstrate passion for research and a comprehensive working knowledge of common in vivo laboratory techniques in the field of bone biology and/or immunology/dermatology are encouraged to apply. A PhD, or MD/PhD in a relevant field and a strong publication record is required. Fluency in English is essential.
Successful candidates will benefit from a dynamic and highly collaborative environment and the opportunity to interact with the extended scientific community at UC Davis, which ranks among the top 10 public research universities in the US, and will be encouraged to present their research at international meetings. For more information about the lab and research projects available please visit www.adamopouloslab.com.
To be considered for the position, please send in a single PDF a detailed CV with methodological expertise, a list of scientific publications, and the contact details of three referees to Iannis@ucdavis.edu. Salary will be according to NIH scale and commensurate with experience. Position available immediately.
Gérontopôle of the Toulouse University Hospital
The Gérontopôle of the Toulouse University Hospital (France) is an internationally-recognized institution for clinical research on age-related conditions, in particular in Alzheimer's disease, frailty and sarcopenia (maintaining autonomy) and nursing homes. With more than 400 healthcare professionals, and given its infrastructures, expertise, and clinical care facilities, the Gérontopôle was selected by the French Ministry of Health and the Secretary of State for Older Adults as national center of excellence. Furthermore, in 2017, the Gérontopôle was designated WHO Collaborating Center for Frailty, Clinical Research and Geriatric Training.
The Gérontopôle is currently recruiting post-docs to be involved in the ongoing research programs in Toulouse (France). Candidates should be able to enhance the Gérontopôle studies through the publication of scientific articles in peer-reviewed journals. Post-docs with PhD in a relevant discipline (e.g., epidemiology, gerontology) should therefore master fluent scientific english, be able to perform statistical analysis and use related software and be globally autonomous in writing articles. Posts are for full-time and fixed-term (period of one year, renewable for one year) appointments.
Applications should include:
• A brief cover letter explaining why you would like to join our Institute (1 page maximum),
• Your Curriculum Vitae including your publications list (no more than 3 pages),
• The PDF files of one or two full-text articles of yours.
Applicants should send all these documents by e-mail to Constance de Seynes (email@example.com) who will forward them to the appropriate person. Please use as object of your e-mail “Application for a position at the Gérontopôle”. Shortlisted applicants will be contacted for a phone interview and a subsequent in-person interview in Toulouse.
Humanitas Clinical and Research Centre
The “Beppe and NuccyAngiolini” Foundation is a not-for-profit organization whose mission is to improve health and well-being through advances in basic and translational research on bone and joint pathophysiology with focus on inflammation, immunity and infectious or neoplastic diseases.
The “Beppe and NuccyAngiolini” Foundation calls for application for two positions (post-doctoral fellow and PhD student) to conduct research projects in the general field of its mission at the Humanitas Clinical and Research Center, Rozzano, Milan, Italy (www.humanitas-research.organd www.humanitasricerca.org) and Istituto di RicercheFarmacologicheMario Negri, Milan, Italy (www.marionegri.it).
Candidates must have aPhD (for the post-doctoral fellowship) or a Master degree (for the PhD studentship), a high degree of motivation in academic research and a good ability to work independently. Skills in cellular and molecular biology, immunology, microbiology and protein biochemistry are required. The two Institutions offer a vibrant, lively environment and access to state of the art technology.
Interested candidates should send their CV for inquiries to firstname.lastname@example.org
University of Aberdeen
Past president (co-opted)
6-8 July 2020, Manchester Metropolitan University
Abstract Submission Deadline: 14 February 2020