Bone Research Society

Bringing basic and clinical researchers together since 1950

Positions Available

Jobs can be publicised here free of charge.  Simply send details to web@boneresearchsociety.org.

Adverts should contain a very brief description (maximum three sentences), an e-mail address or web location for obtaining further details, and the closing date.

Other useful websites when looking for jobs are jobs.ac.uk (University positions in the UK) and www.academicjobseu.com (Europe-wide).

 

Postdoctoral position in Molecular Physiology of Bone

Czech Academy of Sciences
Prague
Closing date: Thu 30 Jun 2022

IPHYS Laboratory of Molecular Physiology of Bone
Czech Academy of Sciences Biomedical Research Campus in Prague, Krč

IPHYS is a leading research institute in the field of normal and pathological physiology. It consists of a number of scientific and service departments and shared equipment for the research (http://www.fgu.cas.cz/en/).
The Laboratory of Molecular Physiology of Bone led by Dr. Michaela Tencerova is focused on studying the physiological role of bone marrow adipose tissue in relation to bone and fat metabolism in metabolic complications (https://www.fgu.cas.cz/en/departments/laboratory-of-molecular-physiology-of-bone).
The research continues work on our previous studies identifying unique metabolic phenotype of bone marrow adipocytes
comparing to peripheral adipose tissue in obesity with a focus on specific targets in the regulation of bone marrow
homeostasis (Tencerova et al, Cell Reports, 2019; Tencerova et al., Bone Res, 2019; Tencerova et al., JBMR 2018). The successful applicant will work in the international and friendly environment. The research project will include the work with murine and human cellular systems (bone marrow stromal stem cells) and animal transgenic models applying highthroughput methods such as RNA sequencing, metabolomics, lipidomics, and bioenergetics. The research will be
conducted in collaboration with prestigious national and international laboratories in USA and Europe and supported by EFSD NovoNordisk grant.
We are recruiting highly motivated scientist on:
Postdoctoral position in Molecular Physiology of Bone

Responsibilities:
• Independent leading project
• design of experiments and their interpretation
• data analysis
• Learning new methods
• Teamwork, helping colleagues with other projects

Position Requirements:
• PhD degree (with up to 8 years from PhD) in molecular biology, biochemistry, physiology, medicine,
or related disciplines
• Motivation to do science, curiosity and thinking outside of box
• Advanced experience with molecular biology techniques, in vitro cell culture methods, cloning, CRISPR
technology, animal work (metabolic assays, drug administration etc.) Basic command of English, PC
literacy
• track record of scientific publications, capability of working in international team, great level of English
in written and spoken form
We Offer:
• Working in creative international environment
• Competitive salary
• Social benefits (e.g. health insurance, language courses, subsidized lunches, kindergarten,
institutional lodging house)
• 6 weeks holiday + 3 sick days
Expected Appointment Start Date: Negotiable

Required Documents:
• Cover Letter
• CV (including the list of publications)
• References
to be sent by the applicant to the contact below by 31.6.2022

Contact: Bc. Marcela Tomášková, BBA marcela.tomaskova@fgu.cas.cz

marcela.tomaskova@fgu.cas.cz

Identifying early changes in bone collagen composition for assessment of bone health

Lancaster University
Lancaster Medical School, Lancaster University
Closing date: Tue 31 May 2022

About the Project

The NHS spends £4.3 billion on musculoskeletal conditions each year, accounting for the third largest area of spending within the NHS. Age related bone disorders include diseases such as osteoarthritis (OA) and osteoporosis (OP) (1). OA affects 1/3 of adults over the ages of 45. OP affects 22% of women over 50 years of age, and this increases to 50% of women over the age of 80 years. X-ray based diagnostic techniques are the most widely used method for diagnosing bone disorders. However, these methods of diagnosis can only determine changes to gross anatomical bone structure, and do not identify more subtle biochemical changes within bone.

Bone is a mixture of organic and inorganic components. The organic component includes proteins, such as collagen. Changes to bone collagens are associated with disease, although current bone diagnostic methods do not assess this. A reduction in collagen content of bone can result in a brittle phenotype and fracture, such as in osteoporosis.

Raman spectroscopy is a non-invasive, laser-based method that can detect changes to the protein component of bone (2). This technique has potential to provide information about changes in bone diseases and is currently being developed for in vivo use (3). Elevation of collagen types II and X within human blood serum have both been identified as biomarkers of osteoarthritis through ELISA techniques. Raman spectroscopy has the potential to identify these biomarkers within human whole blood and serum (4).

The aim of this project is to test the hypotheses that the different types of collagen (types I – XI) in the human body are detectable, and distinguishable, by Raman spectroscopy.

To test this hypothesis, the project aims to:

1. To measure purified human collagen (types I – XI) using Raman spectroscopy.

2. To grow human osteoblast-like cell lines under different physiological conditions to examine differences in the collagen types secreted using Raman spectroscopy, enzyme linked immunosorbant assays (ELISA) and western blotting techniques.

3. To use Raman spectroscopy to identify changes in circulating blood collagen types in blood samples from patients with OA, OP and control (subject to ethical approval; the supervisory team have previously submitted successful IRAS applications and will guide the student through this process).

This study will be valuable for both non-invasively assessing changes to bone proteins and for using free-floating collagen levels within human blood serum as biomarkers for bone diseases. This will be of interest for bone biochemistry, therapeutic development and bone disease research. Developing a reference of collagen spectra will also have far ranging uses in medical diagnostics and in analytical chemistry.

The student will join a friendly and supportive wider research group, and prior experience in the relevant laboratory techniques are not required as training will be provided. This project would suit a student with a background in biomedicine/biology/chemistry, and who has a strong academic track record.

Throughout the PhD, the successful student can expect to receive training in:

- Vibrational spectroscopy

- Statistical analysis

- Biological laboratory skills such ELISAs/western blotting techniques

- Applying for NHS research ethical approval

- Experience in writing peer-reviewed publications

Additionally, there may be some opportunities to gain teaching experience and participate in public engagement activities alongside this project.

This research will be disseminated through peer -reviewed publications (Journal of Bone and Mineral Research, Bone, Analytical Chemistry, Analyst) and at national and international conferences.

For an informal chat about this project, please e-mail rebecca.shepherd@lancaster.ac.uk.

Application process: Applications should be made in writing to the lead supervisor, Dr Rebecca Shepherd (rebecca.shepherd@lancaster.ac.uk). You MUST include the following

1. CV (max 2 A4 sides), including details of two academic references

2. A cover letter outlining your qualifications and interest in the studentship (max 2 A4 sides)

Funding Notes

The full-time studentships are tenable up to 3 years full-time (subject to satisfactory progress) and will cover the cost of tuition fees at Home/EU rates alongside a stipend in line with the UK Research Council is payable.

It is expected the successful applicant will commence 1st October 2022.

References

Key references

1. Shepherd RF, Kerns JG, Ranganath LR, Gallagher JA, Taylor AM. Lessons from Rare Forms of Osteoarthritis. Calcified tissue international. 2021 Aug;109(3),291–302.

2. Kerns JG, Gikas PD, Buckley K, Shepperd A, Birch HL, McCarthy I, et al. Evidence from Raman Spectroscopy of a Putative Link Between Inherent Bone Matrix Chemistry and Degenerative Joint Disease. Arthritis Rheumatol. 2014 May;66(5):1237–46.

3. Buckley K, Kerns JG, Gikas PD, Birch HL, Vinton J, Keen R, et al. Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy. IBMS Bonekey. 2014;11.

4. Atkins CG, Buckley K, Blades MW, Turner RFB. Raman Spectroscopy of Blood and Blood Components. Appl Spectrosc. 2017 May 11;71(5):767–93.

Read more...
rebecca.shepherd@lancaster.ac.uk

Post-doctoral Research Scholar

University of California at Davis, School of Medicine, and Division of Rheumatology
UC Davis Medical Center, Shriners Hospitals-Northern California

The successful candidate will work in a NIH-funded laboratory with access to state-of-the-art facilities that investigates cytokine regulation of autoimmunity. Self-motivated, scholars that demonstrate passion for research and a comprehensive working knowledge of common in vivo laboratory techniques in the field of bone biology and/or immunology/dermatology are encouraged to apply. A PhD, or MD/PhD in a relevant field and a strong publication record is required. Fluency in English is essential.

Successful candidates will benefit from a dynamic and highly collaborative environment and the opportunity to interact with the extended scientific community at UC Davis, which ranks among the top 10 public research universities in the US, and will be encouraged to present their research at international meetings. For more information about the lab and research projects available please visit www.adamopouloslab.com.

To be considered for the position, please send in a single PDF a detailed CV with methodological expertise, a list of scientific publications, and the contact details of three referees to Iannis@ucdavis.edu. Salary will be according to NIH scale and commensurate with experience. Position available immediately.

Read more...
Iannis@ucdavis.edu

Research job opportunity

Gérontopôle of the Toulouse University Hospital
Toulouse, France

The Gérontopôle of the Toulouse University Hospital (France) is an internationally-recognized institution for clinical research on age-related conditions, in particular in Alzheimer's disease, frailty and sarcopenia (maintaining autonomy) and nursing homes. With more than 400 healthcare professionals, and given its infrastructures, expertise, and clinical care facilities, the Gérontopôle was selected by the French Ministry of Health and the Secretary of State for Older Adults as national center of excellence. Furthermore, in 2017, the Gérontopôle was designated WHO Collaborating Center for Frailty, Clinical Research and Geriatric Training.

The Gérontopôle is currently recruiting post-docs to be involved in the ongoing research programs in Toulouse (France). Candidates should be able to enhance the Gérontopôle studies through the publication of scientific articles in peer-reviewed journals. Post-docs with PhD in a relevant discipline (e.g., epidemiology, gerontology) should therefore master fluent scientific english, be able to perform statistical analysis and use related software and be globally autonomous in writing articles. Posts are for full-time and fixed-term (period of one year, renewable for one year) appointments.

Applications should include:
• A brief cover letter explaining why you would like to join our Institute (1 page maximum),
• Your Curriculum Vitae including your publications list (no more than 3 pages),
• The PDF files of one or two full-text articles of yours.

Applicants should send all these documents by e-mail to Constance de Seynes (constance.de-seynes@univ-tlse3.fr) who will forward them to the appropriate person. Please use as object of your e-mail “Application for a position at the Gérontopôle”. Shortlisted applicants will be contacted for a phone interview and a subsequent in-person interview in Toulouse.

CALL FOR APPLICATIONS (POSTDOC AND PHD) IN BONE PATHOPHYSIOLOGY

Humanitas Clinical and Research Centre
Milan Italy

The “Beppe and NuccyAngiolini” Foundation is a not-for-profit organization whose mission is to improve health and well-being through advances in basic and translational research on bone and joint pathophysiology with focus on inflammation, immunity and infectious or neoplastic diseases.
The “Beppe and NuccyAngiolini” Foundation calls for application for two positions (post-doctoral fellow and PhD student) to conduct research projects in the general field of its mission at the Humanitas Clinical and Research Center, Rozzano, Milan, Italy (www.humanitas-research.organd www.humanitasricerca.org) and Istituto di RicercheFarmacologicheMario Negri, Milan, Italy (www.marionegri.it).
Candidates must have aPhD (for the post-doctoral fellowship) or a Master degree (for the PhD studentship), a high degree of motivation in academic research and a good ability to work independently. Skills in cellular and molecular biology, immunology, microbiology and protein biochemistry are required. The two Institutions offer a vibrant, lively environment and access to state of the art technology.
Interested candidates should send their CV for inquiries to direzione.scientifica@humanitasresearch.it

direzione.scientifica@humanitasresearch.it

BRS Annual Meeting 2022
BRS Annual Meeting 2022

6-8 July 2022, Manchester Metropolitan University, Manchester, UK

Meet the Committee

Scott Dillon
University of Cambridge
Non-clinical new investigator representative